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Amphiregulin is an essential mediator of estrogen receptor alpha function in mammary gland development. Evidence that an early pregnancy causes a persistent decrease in the number of functional mammary epithelial stem cells — implications for pregnancy-induced protection against breast cancer. This may result in failure of some genuine stem cells to form outgrowths or may allow more differentiated progenitors to reacquire primitive stem cell-like features and generate outgrowths, as has been recently reported for differentiating spermatogonial progenitors [ 43 ]. Authors' contributions KB contributed to the study design, isolated mammary cell populations for transplant, analysed transplanted tissues, developed immunostaining protocols, stained and analysed tissue sections and assisted with writing manuscript. Relation of Nutrition to. JLR and GM assisted with transplantations and produced lentivirus.
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